Raman: Unlocking its full potential

Raman spectroscopy, the gold standard in advanced analytical technologies, enables the detection of substances, the verification of their authenticity and the analysis of their efficacy by deciphering transdermal mechanisms, all without altering the studied matrix. The Chinese National Institute for Food and Drug Control has identified four areas for optimisation, which are currently under investigation: miniaturising confocal spectrometers for in situ analysis; hybridising this technique with infrared or electron microscopy; using CARS and SRS to enhance spatial resolution; and integrating deep learning to address spectral overlap and fluorescence. The final steps towards standardisation will be the development of anti-fluorescence laser sources, the creation of standardised spectral databases, cost reduction, and regulatory validation.